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Episode 205: More chest x-rays lead to earlier lung cancer diagnoses and better cancer survival – what we can be doing differently in practice

Today, we’re speaking to Dr Steve Bradley, GP and Senior Clinical Lecturer based within the School of Medicine and Population Health at the University of Sheffield.

Title of paper: General practice chest X-ray rate is associated with earlier lung cancer diagnosis and reduced all-cause mortality: a retrospective observational study

Available at: https://doi.org/10.3399/BJGP.2024.0466

The study was funded by Cancer Research UK.

It is known that there is wide variation in the use of chest X-ray (CXR) by general practices, but previous studies have provided conflicting evidence as to whether greater utilisation of them leads to lung cancer being diagnosed at an earlier stage and improves survival. This observational study analysed data from the English national cancer registry on CXR rates for individual general practices, along with stage and survival outcomes; it found earlier stage at diagnosis and improved survival for patients diagnosed with cancer at practices that used the test more frequently. Increasing use of CXR by GPs for symptomatic patients, particularly by focusing on practices that use the test infrequently, could improve lung cancer outcomes.

Other papers we discussed in today’s podcast
NICE NG12 guidelines highlighting symptoms for which urgent CXR recommended https://www.nice.org.uk/guidance/ng12/chapter/Recommendations-organised-by-site-of-cancer#lung-and-pleural-cancers
Previous paper looking at GP endoscopy rates and upper gastrointestinal cancers https://gut.bmj.com/content/63/2/250?ijkey=80f16b3900505025f06dc3117ec4d5f539bfb02a&keytype2=tf_ipsecsha
Editorial on role of GPs in lung cancer screening https://bjgp.org/content/73/733/340
Roy Castle Lung Cancer Foundation recommendations on symptomatic lung cancer diagnosis (including recommendation on self request services) https://bjgp.org/content/75/750/40
Earlier study showing high variation in CXR use that isn’t accounted for by differences in general practices or their populations https://bjgp.org/content/72/714/e34
Overview of guidelines worldwide showing that CXR is recommended first line test from general practice in almost every jurisdiction (aside from Denmark) https://bjgp.org/content/73/727/84
Editorial discussing how GPs work through the challenge of  assessing risk with negative tests like CXR https://bjgp.org/content/71/708/298
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